If your doctor thinks you might have brain cancer, exams and tests will be required to reach an accurate diagnosis. This begins with your physician asking questions about your health history, symptoms, risk factors and family history of disease. Your doctor will likely examine you for possible signs of brain or spinal cord problems. The exam will test things like your reflexes, muscle strength, sensation, eye and mouth movement, vision, coordination, and alertness. More in-depth tests include:
- Magnetic Resonance Imaging (MRI): An MRI scanner uses magnets and strong radio waves to make pictures of the brain. MRIs are very useful in diagnosing brain tumors because they allow your doctor to "see through" your skull. It can show smaller details better than other scans.
- Computed Tomography (CT) Scan: A CT scan is a type of X-ray that creates detailed pictures of the brain. A computer combines these many images into a useful picture. A special form of CT scan, known as CT angiography, may be used to look at the blood vessels around a tumor to help plan surgery.
- Positron Emission Tomography (PET) Scan: A PET scan can help your doctor tell the difference between an active, growing tumor and damage from radiation therapy or a scar from surgery. For a PET scan, a technician injects a small amount of a radioactive substance into your vein. Fast-growing tissue, such as a tumor, absorbs this substance and can be seen by a special type of scanner. The radioactive material used in this test is not dangerous and will leave your body in about 6 hours.
- Magnetic Resonance Spectroscopy (MRS): An MRS scan can determine the metabolites inside the tumor. Sometimes, this test is used to determine if a growth is an active tumor or a mass of radiation damage (necrosis).
- Angiogram: An angiogram is a series of X-rays taken after a technician injects a special dye into one of your blood vessels. These X-rays show the tumor and the blood vessels that lead to it, which helps doctors plan surgery. CT angiography and magnetic resonance (MR) angiography are now used more often to look at blood vessels in the brain.
- Magnetic Resonance Angiography (MRA): This is a special type of MRI which is less invasive than an angiogram, but certain types of cancer can’t be seen with this method.
- Myelogram: A myelogram is an X-ray of the spine. A technician injects special dye into your cerebrospinal fluid in the spine to help make tumors more visible. This test is rarely done because MRIs offer more information without injecting dye into the spine.
- Skull X-Ray: Skull X-Rays are very good at identifying calcium deposits left by certain types of tumors.
- Lumbar Puncture (Spinal Tap): For this test, a thin, hollow needle is placed into the lower back, into the spinal canal – the area around the spinal cord. The fluid pressure in the spinal canal and brain can then be measured and a small amount of cerebrospinal fluid (CSF) can be removed and sent for testing to see if it contains cancer cells.
- Electroencephalogram (EEG): An electroencephalogram (EEG) is a non-invasive test that uses small round discs with wires (electrodes) placed on your scalp to measure electrical activity in your brain, called brain waves.
- Brain Tumor Biopsy: If any of these tests suggest that a tumor might be present, a neurosurgeon will probably take a biopsy of the tumor. In most cases, this is the only way to know for sure if a tumor is benign or malignant (and to determine what type of tumor it is), although sometimes doctors can get enough information to make a diagnosis from the imaging tests alone. For a brain tumor biopsy, a doctor takes out as much of the tumor as possible through a bone "window" made in your skull. Another type of biopsy is the stereotactic biopsy. For this biopsy, the neurosurgeon removes a small piece of the tumor with a hollow needle.